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Mailing Address:
The Robert H. Smith Institute of
Plant Sciences and Genetics
in Agriculture
POB 12, Rehovot 76100, Israel

Administrator: Neomi Maimon 
Tel: 972-8-948-9251,
Fax: 972-8-948-9899,

Director: Prof. David Weiss
Tel: 972-8-948-9436
Fax: 972-8-948-9899


Seminars and Events

Seminar - Dr. Raul Zavaliev

Wed, 25/11/2020 - 16:00 to 17:00

Dr. Raul Zavaliev 
Department of Biology
Duke University

Protein Condensation as Cell Survival Strategy in Plant Immunity

Zoom meeting
Meeting ID: 899 9888 8303
Passcode: 966627

In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death,
which is restricted by NPR1, an activator of systemic acquired resistance. However, the
biochemical activities of NPR1 enabling it to both promote defense and restrict cell death
remain unclear. In this work we show that NPR1 promotes cell survival by targeting
substrates for ubiquitination and degradation through formation of salicylic acid-induced
NPR1 condensates (SINCs). SINCs are enriched with stress response proteins, including
nucleotide-binding leucine-rich repeat immune receptors, oxidative and DNA damage
response proteins and protein quality control machineries. Transition of NPR1 into
condensates is required for the formation of the NPR1-Cullin 3 E3 ligase complex to
ubiquitinate SINC-localized substrates, such as EDS1 and other key immune regulators to
promote cell survival during ETI. Our analysis of SINCs suggests that NPR1 is centrally
integrated into the cell death/survival decisions in plant immunity by modulating multiple
stress-responsive processes in this quasi organelle.