Dr. Shilo Rosenwasser

Research Interests

Redox regulation of metabolism, stress acclimation, and cell death in photosynthetic organisms.

As sessile organisms that grow under highly variable environmental conditions, plants must constantly sense, respond, and adapt to fluctuation in their environment. Many aspects of adaptation to environmental conditions are believed to be regulated by ROS/redox signals which differ in temporal, spatial and intensity patterns in photosynthetic cells. Oxidation and reduction of thiol proteins, in which their biochemical characteristics changed upon oxidation, is thought to be the major mechanism by which redox signals are integrated into cellular signal transduction pathways.

My group is interested in understanding how signals linked to environmental conditions are translated into alteration in the cellular redox state, sensed by redox sensors, and transmitted into biological pathways to maintain homeostasis by coordinating cellular activities. We are using genetics and functional genomics tools, together with genetically-encoded fluorescent redox sensors and novel quantitative redox proteomics approach. Our primary objective is to systematically decipher and characterize the redox-based signal transduction pathways involved in sensing and acclimating to environmental conditions in plants. We believe that uncovering the plant redox-sensitive protein network will pave the way to produce plants with higher productivity and tolerance to stress.



Open Positions

We are currently looking for lab technician, MSc and PhD students!

To apply please contact shilo.rosenwaser@mail.huji.ac.il




List of Publications

  • Bratt, A. *, Rosenwasser, S.* , Meyer, A., and Fluhr, R. (2016). Organelle redox autonomy during environmental stress. Plant Cell Environ.‏ 39(9):1909-19
  • Rosenwasser, S. , Ziv, C., van Creveld, S. G., and Vardi, A. (2016). Virocell Metabolism: Metabolic innovations during host–virus interactions in the Ocean. Trends Microbiol. 24(10), 821-832.‏
  • van Creveld, S. G. *, Rosenwasser, S. * , Levin, Y., and Vardi, A. (2016). Chronic iron limitation confers transient resistance to oxidative stress in marine diatoms. Plant Physiol. 172(2), 968-979.‏
  • Malitsky, S. *, Ziv, C. *, Rosenwasser, S. * , Zheng, S., Schatz, D., Porat, Z., Ben-Dor, S., Aharoni, A., and Vardi, A. (2016). Viral infection of the marine alga Emiliania huxleyi triggers lipidome remodeling and induces the production of highly saturated triacylglycerol. New Phytol. 210(1), 88-96
  • Sheyn, U., Rosenwasser, S. , Ben-Dor, S., Porat, Z., and Vardi, A. (2016). Modulation of host ROS metabolism is essential for viral infection of a bloom-forming coccolithophore in the ocean. ISME J. doi: 10.1038/ismej.2015.228.
  • Schatz, D., Shemi, A., Rosenwasser, S. , Sabanay, H., Wolf, S., Ben-Dor, S., and Vardi, A. (2014). Hijacking of an autophagy-like process is essential for the life cycle of a DNA virus infecting oceanic algal blooms. New Phytol. 204(4), 854-863.
  • Graff van Creveld, S. *, Rosenwasser, S. , Schatz, D., Koren, I., and Vardi, A. (2014). Early perturbation in mitochondria redox homeostasis in response to environmental stress predicts cell fate in diatoms. ISME J. 9(2), 385-395.
  • Rosenwasser,  S . , Mausz, M.A. *, Schatz, D., Sheyn, U., Malitsky, S., Aharoni, A., Weinstock, E., Tzfadia, O., Ben-Dor, S., Feldmesser, E., Pohnert, G., and Vardi, A. (2014). Rewiring host lipid metabolism by large viruses determines the fate of Emiliania huxleyi, a bloom-forming alga in the ocean. Plant Cell. 26 (6): 2689-2707. 
    Highlight : A virus that enslaves ocean algae by Pamela J. Hines  in Science (2014).doi: 10.1126/science.345.6193.176-a
  • Rosenwasser, S. , Graff van Creveld, S., Schatz, D., Malitsky, S., Tzfadia, O., Aharoni, A., Levin, Y., Gabashvili, A., Feldmesser, E.,  and Vardi, A . (2014). Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment. Proc. Natl. Acad. Sci. U. S. A. 111(7):2740-5.
  • Feldmesser, E., Rosenwasser, S. , Vardi, A., and Ben-Dor, S. (2014). Improving transcriptome construction in non-model organisms: integrating manual and automated gene definition in Emiliania huxleyi . BMC Genomics. 15:148.
  • Mor, A., Koh, E., Weiner, L., Rosenwasser, S. Sibony-Benyamini, H. and Fluhr, R. (2014). Singlet oxygen signatures are detected independent of light or chloroplasts in response to multiple stresses. Plant Physiol. 165(1), 249-261.
  • Rosenwasser, S. Fluhr, R., Joshi J.R., Leviatan, N., Sela, N. , Hetzroni, A., and Friedman, H. (2013). ROSMETER: a bioinformatic tool for the identification of transcriptomic imprints related to reactive oxygen species type and origin provides new insights into stress responses. Plant Physiol. 163(2):1071-83.
  • Rosenwasser, S. , Rot, I., Sollner, E., Meyer, A.J., Smith, Y., Leviatan, N. Fluhr, R., and Friedman, H. (2011). Organelles contribute differentially to reactive oxygen species-related events during extended darkness. Plant Physiol. 156(1):185-201.
  • Rosenwasser, S. , Rot, I., Meyer, A.J., Feldman L., Jiang, K., and Friedman, H. (2010). A fluorometer-based method for monitoring oxidation of redox-sensitive GFP (roGFP) during development and extended dark stress. Physiol Plant. 138(4):493-502.
  • Rosenwasser, S. , Belausov, E. , Riov, J, Holdengreber, V., and Friedman, H. (2010).Gibberellic Acid (GA3) inhibits ROS increase in chloroplasts during dark-Induced senescence of   Pelargonium cuttings. J. Plant Growth Regul. 29: 375-384.
  • Rosenwasser, S. , Mayak, S., and Friedman, H. (2006). Increase in reactive oxygen species (ROS) and in senescence-associated gene transcript (SAG) levels during dark-induced senescence of Pelargonium cuttings and the effect of gibberellic acid. Plant Sci. 170: 873-879.